NIH R01 · 2024
Inter-kingdom interactions of Salmonella Typhimurium and Candida albicans in the gut
PROJECT SUMMARY Polymicrobial infections are a significant health concern to humans. Multi-species biofilms exhibit greatly increased antibiotic resistance, and systemic infections with more than one etiologic agent are difficult to treat and often more lethal than infections with a single pathogen. Salmonella enterica serovar Typhimurium (STm) is a food-borne bacterial pathogen that causes gastroenteritis in over 1.35 million people in the US every year. Recently, a clinical study with 2500 patients uncovered that the under-studied fungal component of the microbiome is an important modulator of Salmonella enterica infections. When patients were colonized with the opportunistic pathogenic…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.