NIH R01 · 2024
Biotin catabolism: an unwritten chapter in the metabolism of an essential vitamin
Biotin is an essential vitamin in the human diet. The adequate daily intake for adult humans is in the range of 30-100 micrograms. The biotin market is divided between agricultural and human use with 90% and 10% going to animal and human nutrition respectively. Currently biotin is produced by chemical synthesis at the level of >20 tons/year. Biotin biosynthesis is well-understood and efforts to produce it by fermentation are currently under intense investigation in several biotechnology companies. Biotin functions as a cofactor in all biochemical carboxylation reactions involving bicarbonate as the CO2 donor. The mechanism of biotin mediated carboxylation is now well-understood. Biotin has…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.