NIH R01 · 2024
RAG-mediated DNA Damage Responses in Immune Development and Function
PROJECT SUMMARY Lymphocyte development is precisely controlled to enable clonal expansion and expression of a diverse immunoglobulin receptor repertoire, which proceeds through DNA double-stranded breaks (DSBs) generated by the RAG endonuclease. These two dichotomous, but interdependent processes, are managed through the cooperation of diverse cellular signals to prevent cells with DSBs from entering cell cycle where they could be aberrantly repaired as translocations. During early B cell development, the pre-B cell receptor (pre-BCR), through activation of the SYK kinase, coordinates both the proliferative expansion of pre-B cells and the assembly of immunoglobulin receptor genes. Negative…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.