NIH R01 · 2024
Development of a vaccination platform for emerging flavivirus infections
Project Summary: The Flavivirus genus (referred to as flaviviruses) consists of numerous emerging and re-emerging global pathogens of critical human significance. Endemic and emerging flaviviruses like dengue virus (DENV), Powassan virus (POWV), Zika virus (ZIKV), West Nile virus, Japanese Encephalitis virus and Yellow fever virus continue to spread and cause significant human disease. We have used RNA structural data from a conserved 3’ untranslated region (UTR) pseudoknot called xrRNA1 to develop an attenuation approach in a highly conserved structural region of the flavivirus 3’UTR for vaccine development. This approach allows us to 1) swap out flavivirus structural genes in our clone to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.