NIH R01 · 2024
Lactate production by tumor associated macrophages promotes tumorigenesis
ABSTRACT Tumor-associated macrophages (TAMs) are the most prevalent immune cell in the tumor microenvironment. TAMs adopt an M2-like phenotype that supports angiogenesis, attenuates anti-cancer immune responses, and facilitates metastatic dissemination. Studies in humans and experimental animal models support targeting TAMs for anti-cancer therapy. However, the environmental conditions triggering M2 polarization and molecular mechanisms mediating this process are poorly understood. This knowledge is required to target TAMs therapeutically and to identify patients that would benefit from such therapies. One potential pathway for TAM polarization is via metabolic reprogramming. Previous…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.