Becker Lab

Research focus

NIH R01 · 2024

Cardiomyocyte selective modulation of natriuretic peptide signaling in cardiomyopathy

Project Summary: In the last 30 years there has been a dramatic increase in our understanding of the genetic and non-genetic mechanisms that contribute to the development of cardiomyopathy in humans. Despite this increased mechanistic understanding, the risk of heart failure and sudden death remains high in this patient population. While multiple small molecule agents reduce the morbidity and mortality of patients with cardiomyopathy, many patients still progress to end stage disease. In addition, these small molecule agents act in a non-cell type specific manner and their utilization is often limited by side effects. Likewise, pharmacological therapy to prevent sudden death in individuals…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.