NIH R01 · 2025
PTEX mechanism in malaria parasite effector protein export and host cell subversion
Project Summary Malaria disease remains a serious public health problem. Progress in Malaria control has slowed in recent years while resistance to frontline antimalarials is emerging in the most afflicted regions, underscoring a pressing need for deciphering fundamental parasite biology to provide novel therapeutic strategies. This obligate intracellular parasite exports a battery of effector proteins out of a vacuolar niche to drastically remodel its host cell, a process that depends on the Plasmodium Translocon of EXported proteins (PTEX). PTEX is built on a vacuole nutrient pore formed by EXP2 which is further functionalized by the adaptor PTEX150 and AAA+ chaperone HSP101 to form the…
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