NIH R01 · 2025
Mechanotransduction Control of CNS Myelin Sheath Length.
Project Summary Loss and changes to central nervous system (CNS) myelin architecture are prevalent in neurological conditions across the lifespan. Incomplete restoration of myelin sheaths, as seen in multiple sclerosis, leads to disability. Our long-term goal is to identify developmental mechanisms controlling CNS myelin formation essential to CNS function, thus informing future therapies that remediate lost and aberrant myelin in neurological diseases. Myelin sheath architecture, particularly length, controls axonal signaling speed. The >10-fold variation in myelin sheath lengths observed in the CNS adjusts neuronal signaling speeds and, therefore, is thought to enable neural network…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.