NIH R01 · 2025
Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children
PROJECT SUMMARY Despite increasing access to antiretroviral therapy (ART) in pregnancy, the >1 million children born annually to pregnant people with HIV (PPHIV) who are HIV-exposed but uninfected (HEU) remain at >2-fold higher risk of growth stunting and infectious morbidity than HIV-unexposed children. Though the origins of adverse HEU child health outcomes are poorly understood, mounting evidence suggests that abnormal microbiome development may play a key role. However, the mechanisms remain elusive, and a better mechanistic understanding is essential to improve care. Our overarching goals are to identify clinical, environmental, diet, and epidemiologic features associated with growth…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.