Beaudin Lab

Research focus

NIH R01 · 2025

ILC2s as drivers of lung dysfunction in response to early-life inflammation

Childhood asthma is a leading cause of chronic disease and hospitalization in children. Viral infections within the first year or two of life are strongly associated with childhood asthma risk, but the immune mechanisms mediating this association are poorly understood. The long-term goal of this proposal is to define how early-life inflammation determines asthma susceptibility by reprogramming the fate and function of type 2 innate lymphoid cells from hematopoietic progenitors during early life. This proposal builds on preliminary data linking Type I interferon-mediated inflammation induced by maternal immune activation with poly(I:C) and associated with common viral infections with a…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.