NIH R01 · 2024
Behavioral Consequences and cellular substrates of plasticity in visual cortex
Detection of novel stimuli that may predict reward or punishment requires long-term memory for, and recognition of, stimuli that are familiar. Novelty detection and familiarity recognition are often impaired in neuropsychiatric disease, so understanding the neurobiological underpinnings is an important goal. We recently discovered that memory of visual stimulus familiarity is stored via synaptic modifications in primary visual cortex of mice. The primary aims of our research are now to (a) identify how information is stored by the collective activity of neurons in primary visual cortex and the reciprocally connected thalamus, (b) pinpoint the key sites in the cortical microcircuit where the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.