NIH R01 · 2024
Small translated ORFs in the 3'UTR enhance translation in vertebrates
Project Summary The prevailing doctrine that messenger RNAs (mRNAs) in higher organisms encode for a single protein has undergone a dramatic revision in recent years. Ribosome and proteomic profiling have revealed a large number of small translated open reading frames (ORF) within previously described “untranslated regions” (UTRs) and long non-coding RNAs. Indeed, some of the peptides derived from small ORFs have been implicated in various fundamental processes (e.g., development). Translation of small ORFs in the 5’UTR, known as upstream-ORFs (uORFs), has been shown to have a profound regulatory effect on gene regulation, independent of the encoded peptide. Further, translation of uORFs…
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