NIH R01 · 2024
Neuroprotective lipid mediators target penumbra in experimental ischemic stroke
Abstract Ischemic stroke is a leading cause of long-term disability in both genders and lacks effective therapeutic options. We propose to study elovanoids (ELVs), which are stereospecific dihydroxylated derivatives of the free fatty acids (FFAs) 32:6n-3 or 34:6n-3 that yield ELV-N32 and ELV-N34, respectively, to protect the stroke penumbra from irreversible damage. The precursors of ELVs are made by the enzyme ELOVL4 (elongation of very long- chain fatty acids protein-4). Our preliminary data showed improved behavior, decreased infarct size, restored blood-brain barrier (BBB) integrity, and upregulation of 76 genes in the ischemic core and penumbra by ELV precursors 32:6n-3 or 34:6n-3 when…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.