NIH R01 · 2024
Decoding LRH-1 Activity in Gut Regeneration and Differentiation
Project Summary/Abstract Background: The primary epithelial stem cell in the intestine has been known for over a decade, leading to important observations in epithelial renewal and injury recovery. These fundamental studies have demonstrated that the intestinal epithelium is a balanced continuum between stemness in the crypt base and differentiation towards the mucosal surface, with complex signaling networks influencing stemness and fate of the differentiating progenitor cells. Several groups have now shown that destruction of intestinal stem cells and/or extensive epithelial damage can be repaired by the dedifferentiation of progenitor cells. Thus, the balance between stemness and…
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