NIH R01 · 2025
Cellular/Molecular Mechanisms of Respiratory Neuronal Chemosensitivity
PROJECT SUMMARY An interoceptive system within the CNS monitors levels of CO2 (or its proxy, H+) and regulates respiratory drive for rapid homeostatic control of blood gases and systemic acid-base balance; dysfunction of this central respiratory chem- oreception is cause or consequence of numerous hypoventilation syndromes. Despite recognition of this chemoreflex system since the early 1900s, and its importance for understanding respiratory (patho)physiology, the identity of the relevant sensory element(s) remains a point of significant controversy largely because none of the candidate cellular sensors and molecular detectors have yet fulfilled the requisite experimental criteria. Moreover,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.