NIH R01 · 2025
Project summary Affecting over half of people living with spinal cord injury (SCI), chronic neuropathic pain can have a disastrous impact on quality of life. Despite recent advances in understanding neuropathic pain, its mechanisms remain elusive and it is still largely resistant to available treatments, including opioids. Increasing evidence indicates that mechanisms important for chronic SCI pain are located within the cell bodies of nociceptive sensory neurons and their sensory terminals. After moderate contusive injury at the thoracic level in rodents, a nociceptor hyperactive state exhibiting ongoing, apparently spontaneous, firing of action potentials can drive chronic pain. Dorsal…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.