NIH R01 · 2024
Antibody-mediated immunity to Borrelia burgdorferi
Antibody-Mediated Immunity to Borrelia burgdorferi Summary There is an urgent need to better understand mechanisms of immune protection and pathogenesis of Borrelia burgdorferi (Bb), the causative agent of Lyme disease. This proposal aims to advances understanding of anti-Bb immunity and its failure to clear Bb infections in its natural reservoir hosts. Antibodies control Bb infection, although they cannot clear the infection. Binding of IgG to host cells via activating Fcg receptors (FcgR) and complement receptors (CR1/2) supports innate cell-mediated destruction of pathogens and antigen presentation for adaptive immune response induction. In contrast, engagement of the inhibitory FcgRIIb…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.