NIH R01 · 2024
Genetic and Genomic Analysis of Starvation Resistance in C. elegans
PROJECT SUMMARY By governing growth and quiescence, nutrient-responsive pathways are central to cancer, diabetes and aging. The function of these pathways in starvation informs understanding of their dysfunction in disease, but their fundamental role in starvation is not well understood. The premise of this proposal is that multiple tumor sup- pressors are known to promote starvation resistance, but their regulatory relationships and effector mecha- nisms are unclear. The long-term goal of this project is to elucidate the genetic foundation and molecular mechanisms of starvation resistance in C. elegans as a model for human disease. Worms are an ideal model since they thrive in feast and…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.