NIH R01 · 2024
Molecular Mechanisms of TRIB1 Regulation of Hepatic Metabolism
PROJECT SUMMARY The 8q24 genomic locus, containing the gene Tribbles pseudokinase 1 (TRIB1) has been repeatedly linked via human genome-wide association study with multiple cardiometabolic parameters. This includes plasma total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, coronary artery disease (CAD), circulating liver enzymes and non-alcoholic fatty liver disease (NAFLD), circulating adiponectin, and HbA1c. This constellation of genetic associations is unique in the genome, and suggests that TRIB1 is a critical regulator of human metabolic health. Many of these traits are governed by hepatic metabolism, and knockout and overexpression studies in mouse livers have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.