Adams Lab

Research focus

NIH R01 · 2025

Pooling International Cohort Studies of Long-Term Bisphosphonate Use and Atypical Femur Fractures

Project Summary Use of bisphosphonate (BP) medications for the prevention of fractures is declining, partially due to patient and provider fears about the occurrence of atypical femur fractures (AFF), which are clearly associated with long- term bisphosphonate use. Many individuals are choosing to not use these medications at all rather than risk having this rare outcome. This decision may leave individuals at high risk of morbidity and mortality. Balancing the risk of typical osteoporosis-related fractures, such as hip or vertebral fractures, with the risk of the much rarer AFF, is an important component of decision-making by physicians and patients about medication use. Further, an…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.