Batmanghelich Lab

Research focus

NIH R01 · 2025

Integrating Multi-Modal Data and Biomechanics in COPD: Toward Robust and Interpretable Biomarkers for Disease Subtyping and Progression

Abstract Chronic Obstructive pulmonary disease (COPD) is a devastating, progressive disease affecting 13 million Americans and 300 million globally. The disease is highly heterogeneous, with both behavioral risk (e.g., smoking) and genetic predisposition. Patient-specific biomechanics also play a crucial role in determining the progression of the disease. While the global lung function test is used for clinical diagnosis, it is insufficient to understand the underlying mechanism of the disease. High-resolution CT imaging is also used to quantify the two major phenotypes of the disease (e.g., emphysema and airway inflammation). However, current classical radiomics measures lack the…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.