NIH R01 · 2025
Investigating Syngap1 as a regulator of striatal synaptic function
PROJECT SUMMARY SYNGAP1-related intellectual disability is a neurodevelopmental disorder caused by mutations in the SYNGAP1 gene. SYNGAP1 encodes SynGAP, which is a highly abundant protein in the post- synaptic density of excitatory synapses. At synapses, SynGAP functions to repress downstream NMDAR signaling and AMPAR trafficking through its inhibition of small GTPases. Translocation of SynGAP out of the post-synaptic density is required to allow NMDAR-dependent long-term potentiation (LTP) in cultured neurons. In the absence of SynGAP, NMDAR-dependent plasticity is unrestrained leading to alterations in synapse strength, spine structure, and plasticity. While the functions of SynGAP have…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.