Bates Lab

Research focus

NIH R01 · 2025

Preserving Epithelial Barrier Integrity in Ventilator-Induced Lung Injury

PROJECT SUMMARY Up to 40% of ARDS patients lose their battle with acute respiratory distress syndrome (ARDS). Many of these patients succumb because ongoing ventilator-induced lung injury (VILI) overwhelms the innate capacity of the lung to repair itself. On the other hand, many ARDS patients go on to recover, which means that their reparative capacities eventually prevail. Since there are currently no medical therapies for ARDS, minimizing its mortality amounts to achieving an optimal balance between spontaneous tissue repair versus the generation of VILI. However, one-size-fits-all strategies for managing ARDS have had limited success in reducing mortality, and the heterogeneity of ARDS…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.