NIH R01 · 2025
Calculating the Components of Work of Breathing in Neonates with Bronchopulmonary Dysplasia
Project Summary Neonates can now survive premature birth from as early as 22 weeks’ gestation, but often suffer from bron- chopulmonary dysplasia (BPD) – chronic lung disease of prematurity. BPD consists of several phenotypes – hyperdense lung consisting of fibrotic tissue or inflammation, hyperinflated airspaces, and airway collapse at various levels from the upper airway to the distal airways. However, even if a patient’s phenotypes are identified, there is no mechanism to calculate the relative contributions of the phenotypes to disease severity and symp- toms. Therefore, the goal of this proposal is to create and validate a tool to calculate the contribution of each BPD phenotype. Such…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.