NIH R01 · 2024
Genetics and Immune Predictors for Recurrent Glomerular Diseases in the Kidney Allograft
PROJECT SUMMARY/ABSTRACT The recent development of potent immunosuppressive regimens has led to decreased incidence of acute rejection and increased incidence of non-rejection complications, including recurrent immune-mediated glomerular diseases (GD) which have emerged as leading causes of kidney allograft failure. IgA nephropathy (IgAN), membranous nephropathy (MN), and diffuse podocytopathy (DP) are the most common causes of primary GD in the native kidney and these same GD can recur after transplantation. In the native kidney, it is apparent that immune and genetic factors are important contributors to each of these GD. Although little is known about the pathogenesis of recurrent GD…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.