NIH R01 · 2024
Transcriptional regulation of Myelopoiesis
Abstract Myeloid cells are amongst the first responders to pathogenic insults, but there remains a substantial knowledge gap concerning mechanisms that control their development in the bone marrow (BM). We have found that the transcription factor ThPOK (T-helper-inducing POZ-Kruppel factor) plays a critical unexpected role in myeloid lineage differentiation, as ThPOK null mice show expansion of neutrophil progenitors and precursors in the BM, leading to neutrophilia and protection against sepsis. Loss of ThPOK expression causes widespread transcriptional reprogramming throughout myelopoiesis. Here, we propose to test the hypothesis that ThPOK serves as a transcriptional checkpoint for…
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