NIH R01 · 2024
Role of microglial phagocytosis in prion diseases
Prion diseases or Transmissible Spongiform Encephalopathies are transmissible neurodegenerative diseases in humans and animals that have no treatment and are 100% lethal. The transformation of glia into reactive states is recognized as one of the major hallmarks of neurodegenerative diseases including prion, Alzheimer’s, and Parkinson’s diseases. Conflicting data exist on whether in prion diseases, reactive microglia are protective or deleterious. Microglia are regarded as the main cells in CNS responsible for phagocytosis, yet the role of microglia-driven phagocytosis in prion disease has never been systematically examined. The current project is designed to fill this knowledge gap. Our…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.