NIH R01 · 2024
Fluorescence image guided surgery, adjuvant PDT, and the immune response
Abstract. Prostate cancer (PCa) is the most prevalent cancer among men in the United States and radical prostatectomy remains one of the three treatment options for these patients. Screening with serum prostate specific antigen (PSA) allows for 78% of prostate cancers to be diagnosed at the early localized stage, facilitating therapy with radical prostatectomy (RP) or radiation therapy. However, ∼ 20% patients present with high-risk PCa, i.e., positive surgical margins (PSM) discovered after surgery during pathology of resected tissues. These patients with high-grade tumors also have a high risk of biochemical recurrence (>60%) and will ultimately develop lethal metastatic disease. Surgical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.