NIH R01 · 2025
Mechanisms of Dcc Receptor Signaling in Neuronal Morphogenesis
PROJECT SUMMARY Determining how neurons are assembled into functional circuits will provide insight into developmental disorders of the nervous system and may suggest therapeutic approaches to promote nerve regeneration. To navigate to their correct targets, axons must precisely modulate their responses to extracellular cues. For example, to cross the midline commissural axons must first respond to attractive cues while preventing the response to repulsive cues. After entering the midline, axons switch their response to allow them to be repelled away from the midline to establish connections that are essential for coordinated sensory and motor behavior. Netrin attracts commissural axons to…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.