NIH R01 · 2024
Regulation of TLR trafficking for proper self versus non-self discrimination
PROJECT SUMMARY Inappropriate recognition of self nucleic acids (NA) by members of the Toll-like receptor (TLR) family can result in autoimmune diseases such as lupus and psoriasis. TLR7 (and TLR8 in humans) and TLR9 can be activated by self RNA and DNA, respectively, so defining the mechanisms that limit responses by these TLRs is highly relevant to human health and disease. There is also accumulating evidence that the mechanisms controlling TLR7 and TLR9 responses are distinct, but our understanding of the molecular bases for these differences and their relevance for disease remain poor. This application is a renewal of the grant that has funded our research studying the regulation of…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.