NIH R01 · 2024
Enterovirus RNA Replication and Recombination
PROJECT SUMMARY / ABSTRACT Picornaviruses have both asexual and sexual RNA replication mechanisms. Asexual RNA replication involves one parental template whereas sexual RNA replication involves two or more parental templates. Sexual RNA replication mechanisms optimize the biological fitness of pathogens in enterovirus species A (EV-A71), species B (CVB3), species C (polio and CVA21) and species D (EV-D68). Our study will reveal how these viruses exchange genetic material during sexual RNA replication. Mankind could exploit these mechanisms to control or eradicate important pathogens, from polioviruses to rhinoviruses to EV-D68. Asexual template-dependent RNA replication, while efficient,…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.