NIH R01 · 2024
Inflammaging and Diabetic Retinopathy
PROJECT SUMMARY Diabetic retinopathy (DR) is a neurovascular complication of diabetes mellitus and the leading cause of blindness in adults. Prevention of hyperglycemia-induced retinal microvascular dysfunction remains one of the therapeutic goal to preserve vision in diabetic patients. Recent insights from our group and others have shown that hyperglycemia results in retinal endothelial cells (RECs) stress-induced premature senescence (SIPS), a senomorphic process characterized by the acquisition of the so-called senescence-associated secretory phenotype (SASP) and linked to chronic inflammation. The exact causes and consequences of this mechanism and its relative impact in DR are…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.