NIH R01 · 2025
Project Abstract Left ventricular assist device support is standard therapy for patients with advanced, life-threatening heart failure. However, current-generation impeller-based blood pumps have introduced a new “non-pulsatile” physiology with frequent adverse events. Lack of pulsatility contributes to blood trauma, endothelial and arterial remodeling, and abnormalities in vasoregulation that predispose patients to bleeding, thrombosis, diastolic hypertension, and stroke. Cyclic speed modulation in which device impeller speed is rapidly increased/decreased has been developed to generate pulsatile blood flow. This emerging technology has potential to combine durability of impeller-driven…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.