Bartley Lab

Research focus

NIH R01 · 2025

Impact of Senolytics on Aged Vaccine Responses

PROJECT SUMMARY Despite widespread vaccination, influenza (flu) remains a leading cause of death among older adults. Vaccination is the most effective way to prevent infectious disease. However, older adults have dysregulated immune responses that reduce vaccine efficacy and leave them at risk for severe infection and death. Older adults have reduced T cell proliferation, impaired B cell responses, and decreased antibody titers following flu vaccination. Current methods to improve vaccine efficacy in older adults target singular deficits in immune responses and fail to completely rescue responses. Vaccination requires a complex coordination of multiple cell types and tissues; thus an…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.