NIH R01 · 2024
Dysregulation of calcium signaling in the initiation of fatty liver disease
ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is linked to insulin resistance, type 2 diabetes mellitus (T2DM) and several other major comorbidities. Hepatic carbohydrate and lipid metabolism is maintained by the balance between anabolic hormones, primarily insulin, and catabolic hormones including glucagon and catecholamines. Our novel findings show that norepinephrine (NE) resistance occurs within a week of high fat diet (HFD) feeding in mice. This proposal seeks to determine the molecular mechanisms leading to the suppression of NE signaling and the effect this has on hepatic metabolism and the pathogenesis of NALFD and T2DM. NE and related hormones act through G-protein coupled…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.