NIH R01 · 2024
Impact of TNF on Oncolytic Virotherapy
Project Summary: Oncolytic virotherapy (OV) represents a novel method to treat a variety of solid tumors by inducing anti-tumor immune responses. While this therapy has been extremely efficacious in a wide variety of preclinical models, translating these successes into human patients has proven challenging. It has recently become clear that one of the major reasons for these failures is the existence of immune-regulatory mechanisms which dampen the efficacy of virally induced anti-tumor immunity. However, the exact nature of these regulatory pathways remains unclear. Our lab has previously developed a novel oncolytic MYXV which expresses a soluble PD1 inhibitor and an IL12 fusion protein…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.