NIH R01 · 2025
Type 2 Inflammation and Remodeling Elicited Through an LTE4/OXGR1-dependent pathway
PROJECT SUMMARY Tuft cells are a specialized epithelial cells (EpCs) that initiate airway type 2 inflammation (T2I) through their generation of IL-25 and pro-inflammatory lipid mediators, cysteinyl leukotrienes (CysLTs). We previously reported that airway tuft cells are indirectly activated by common aeroallergens through damage-associated molecular patterns (DAMPs), including the release of ATP and the activation of P2Y2 on tuft cells. Because tuft cells recognize tissue damage, and are detected in settings of airway injury in mouse and humans, we and others have speculated that they may have a role in lung repair, but thus far no such function has been demonstrated and the mechanism(s) by…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.