NIH R01 · 2025
Elucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body Dementia
Cognitive fluctuations (CF) are a hallmark of Lewy body dementia (LBD), presenting as spontaneous, unpredictable episodes of reduced attention and alertness. In addition to being common, CF in LBD are associated with greater impairment in activities of daily living, worse quality of life, and greater healthcare costs. Despite their high prevalence and negative impact, the mechanisms underlying CF are poorly understood. This project aims to elucidate the role of central cholinergic degeneration in CF in LBD, addressing critical gaps in understanding. This project will also establish a paradigm for assessing CF in real-time and focus future therapeutic development. CF in LBD have been linked…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.