NIH R01 · 2024
ER calcium handling, single cell processing, and neural circuit function in vivo
Summary Calcium is a critical second messenger in neurons, regulating neuronal processes from dendritic integration to synaptic transmission. The endoplasmic reticulum (ER) is the major intracellular calcium store in neurons, and aberrant ER calcium signaling is associated with many neurodegenerative disorders. However, it is unclear how ER calcium signaling regulates neuronal function and neural circuit stability. We aim to directly interrogate the link between ER calcium handling, single cell processing, and neural circuit function in vivo. To that end, we will take an imaging approach to simultaneously measure and manipulate physiological neuronal signals and ER calcium dynamics in the…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.