NIH R01 · 2024
Mechanisms in COPII-Dependent Transport
Project Summary Accurate protein transport in the secretory pathway is vital for cell function and growth. Our research program is focused on coat-dependent sorting mechanisms that drive protein trafficking between the endoplasmic reticulum (ER) and Golgi complex. Nascent secretory proteins are translated at the ER and then fully folded proteins are selectively packaged into COPII coated vesicles for anterograde transport to the Golgi complex. This forward pathway is balanced by retrograde transport from the Golgi, which selectively returns proteins to the ER in COPI coated vesicles. To ensure delivery of only folded secretory proteins, a process known as ER quality control largely retains…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.