NIH R01 · 2024
Capturing spatial patterns of new M. tuberculosis infection in Kampala, Uganda
Abstract The standard approach to TB control relies on detection and treatment of Mycobacterium tuberculosis (Mtb) disease. This approach may have limited effectiveness in areas where the high burden of TB leads to high levels of transmission. To curb the TB epidemic, new cases must be prevented. Preventive therapy is an effective intervention as it reduces the risk of progression to disease by 65 – 85% in both HIV-positive (HIV+) and negative (HIV-) individuals. A monumental challenge still remains: one-quarter of the world's population is infected with Mtb. Treating all individuals with LTBI is not feasible: a strategy to identify those at highest risk for progression to TB is required.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.