NIH R01 · 2024
Antibody Landscape following Human Norovirus Infection and Vaccination
Abstract Human noroviruses (HuNoV) are the major cause of acute non-bacterial, epidemic gastroenteritis, resulting in ~200,000 deaths/year, mostly in infant, elderly and immunosuppressed groups. HuNoV vaccines are under development but the results are mixed, in part reflecting antigenic seniority, virus diversity and escape. Our premise is that the function, epitope specificity and atomic level understanding of the virus type specific and broadly cross reactive epitopes in the virion that elicit neutralizing antibody will reveal the mechanisms of protective humoral immunity, which in turn is required for the design of more effective immunogens and vaccination strategies. Consequently, our…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.