Barcellos-Hoff Lab

Research focus

NIH R01 · 2024

Investigating the Genesis of Tumor Immune Microenvironment (TIME) as a function of Inflammation

Contact PD/PI: Barcellos-Hoff, Mary H ABSTRACT The type and pattern of immune cell infiltrate in breast cancer is of growing clinical importance as they associate with response to therapy and are the specific target of immunotherapy. `Cold' cancers that lack infiltrating T cells exhibit pronounced transforming growth factor β (TGFβ) activity and predict poor outcomes in breast cancer patients. However, the factors that influence the genesis of the type of tumor immune microenvironment (TiME) have yet to be defined. We found that radiation-preceded breast cancers in women treated with radiation therapy for Hodgkin's lymphoma are significantly enriched for TiME devoid of lymphocytes and rich…

From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.