NIH R01 · 2024
Peptide-vaccine development against Lyme disease
Project Summary Lyme disease is an endemic tick-borne disease associated with debilitating manifestations such as arthritis, muscle pain, carditis, meningitis, and encephalomyelitis. Despite extensive efforts in the field, there is still no vaccine for the prevention of this infection available for human use. To address this problem, our laboratory has developed novel methodologies to identify antigens relevant during bacterial infection in ticks and mammals and design peptide antigens based on extracellular and conserved regions of these proteins. Our hypothesis for this work is that peptides based on outer-membrane proteins expressed in various phases of the enzootic cycle of B.…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.