NIH R01 · 2025
Biomarkers of Tissue Tolerance and Behavior in a Rat Model
Repetitive overuse induced musculoskeletal injuries (MSKls) are the leading cause of pain and physical disability worldwide, Treatment has proved difficult We believe that 4 issues underlie this problem - (1) the frequent, yet incorrect, assumption that occupational physical activity is as equally beneficial as voluntary exercise; (2) a failure to consider how pathological processes vary and interact over time; (3) underinvestigation of sex-linked differences and consequences of aging ("inflammaging" and reduced repair); and (4) overlooking what we hypothesize are key factors involved in the transition to chronicity, e,g,, poor sleep and fibrotic/degenerative processes, It is time to take a…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.