NIH R01 · 2025
Increasing the protective capacity of antibodies by enhancing Fc-mediated responses
Project Summary Vaccines are powerful tools against microbial pathogens; however, it has not been possible to elicit antibodies that neutralize each pathogen nor to generate sufficient neutralizing antibodies in each person. Along with neutralizing antibodies, vaccines and infection often generate non-neutralizing antibodies that can provide protection through cell-dependent and cell-independent mechanisms. Mechanisms that require the Fc portion of IgG antibodies include antibody-dependent cell-mediated cytotoxicity and phagocytosis (ADCC and ADCP, respectively) and complement-dependent cytotoxicity (CDC). Unfortunately, protection from non-neutralizing antibodies often proves inferior…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.