NIH R01 · 2025
Stressor controllability: Prefrontal circuits that produce resilience and dominance
Project Summary/Abstract The degree of behavioral control that an organism (rodent to human) can exert over an adverse event is arguably the most potent variable yet discovered that modulates the impact of that event. When the organism does have an element of control, the behavioral and neurochemical sequelae of the adverse event are blunted or eliminated. Importantly, the experience of control not only blunts the impact of the stressor being controlled, but also blunts the impact of stressors experienced much later, that is, control produces future resilience in the face of adversity. Research over the past grant period has indicated that control does so by activating distinct circuits…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.