NIH R01 · 2025
Identification of Covalent Transcriptional Dependencies in Melanoma
PROJECT SUMMARY/ABSTRACT Advances in human genetics have identified 400+ genes that when amplified or mutated promote tumorigenesis. While there has been substantial success in developing drugs for kinases and metabolic enzymes deregulated in cancer, they represent only a tiny fraction of the cancer drivers discovered to date. The vast majority (~80%) of these cancer drivers remain undrugged, in part, because of their druggability remains unknown. Among these undrugged oncogenes are transcription factors which represent a large fraction of cancer drivers but are notoriously considered undruggable. To address this challenge, our lab has deployed state-of-the art cysteine-focused chemical…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.