NIH R01 · 2024
In vivio single-cell analysis of dynamic cell behaviors
Imaging plays an increasingly important role in studying development and complex tissue formation across molecular, cellular and tissue levels. Fluorescence 3D time-lapse imaging allows every cell in a tissue or entire organism to be imaged, tracked and measured over hours and days to analyze lineage differentiation and dynamic cell behaviors. Other modalities, e.g., electron and expansion microscopy reveal fine structural phenomena, while emerging genomics technologies, e.g., spatial transcriptomics, seek to merge with microscopy to further provide systematic molecular information. Effective tools of image analysis are crucial to extract, integrate and interpret the information. We propose…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.