NIH R01 · 2024
Reprograming Macrophages and Targeting Glioma Stem Cells in Glioblastoma
Project Summary Glioblastoma (GBM) is the most lethal primary brain tumor with poor prognosis. GBM contains heterogeneous cancer cells including glioma stem cells (GSCs) and harbors abundant tumor-associated macrophages (TAMs). Because the majority of TAMs are tumor-promoting macrophages (pTAMs, M2) that support malignant growth and augment immune suppression, reprograming pTAMs into tumor-suppressive TAMs (sTAMs, M1) to activate macrophage phagocytosis of tumor cells represents an attractive therapeutic strategy. As pTAMs actively interact with GSCs to promote tumor growth and therapeutic resistance, redirecting pTAMs into sTAMs may synergize with targeting GSCs to suppress GBM growth. To…
From the public funding record at NIH RePORTER. Describes the funded project, not the reviews below.